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Zingre, T.; Bagatella, S.; Wenker, C.; Kittl, S.; Meli, M.L.; Wyss, F.; Grau-Roma, L.
Fatal gastritis and enterocolitis due to concurrent _Helicobacter pylori_ and _Campylobacter jejuni_ infection in a captive cheetah (_Acinonyx jubatus_)
2023  Journal of Comparative Pathology (201): 81-86

A 3.5-year-old female cheetah (_Acinonyx jubatus_) died after a 10-day history of anorexia, regurgitation and diarrhoea despite symptomatic therapy. At gross post-mortem examination, the stomach was blood-filled with mucosal thickening and multifocal ulcerations. The intestinal mucosa was thickened and reddened, and the intestinal lumen was filled with dark red to black pasty content. Gastric histological lesions were compatible with gastritis due to _Helicobacter _infection, which was confirmed by polymerase chain reaction. Histology of the intestines revealed a severe necrotizing neutrophilic enterocolitis with abundant intralesional curved to spiral bacteria, corresponding to _Campylobacter jejuni_, which were subsequently isolated from both small and large intestinal contents. No other intestinal pathogens were detected despite thorough investigations. These findings suggest that _C. jejuni _may have played an aetiological role in the enterocolitis. Such an association has not been previously reported in non-domestic felids.

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