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Dolz, G.; Lecis, R.; Solorzano-Morales, A.; Aguilar-Vargas, F.; Solorzano-Scot, T.; Pena, R.; Zobba, R.; Tore, G.; Pitau, M.; Albert, A.
_Leopardus wiedii_ Papillomavirus type 1, a novel papillomavirus species in the tree ocelot, suggests Felidae Lambda papillomavirus polyphyletic origin and host-independent evolution
2020  Infection, Genetics and Evolution (81): 1-9

The limited knowledge on _Papillomavirus _diversity (particularly in wild animal species) influences the accuracy of PVs phylogeny and their evolutionary history, and hinders the comprehension of PVs pathogenicity, especially the mechanism of virus - related cancer progression. This study reports the identification of _Leopardus wiedii Papillomavirus_ type 1 (LwiePV1), the first PV type within_ Lambda papillomavirus_ in a _Leopardus_ host. LwiePV1 full genome sequencing allowed the investigation of its taxonomic position and phylogeny. Based on results, LwiePV1 should be assigned to a novel PV species providing evidence for a polyphyletic origin of feline lambda PVs, and representing an exception to co-divergence between feline lambda PVs and their hosts. Results improve our knowledge on PV diversity and pave the way to future studies investigating biological and evolutionary features of animal PVs.

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