IUCN / SSC Cat Specialist Group - Digital Cat Library |
|
||||||||||
|
||||||||||
|
|
| Prentice, M.B.; Bowman, J.; Wilson, P.J. | |
| A test of somatic mosaicism in the androgen receptor gene of Canada lynx | |
| 2015 BMC Genetics (16): 125-131 | |
The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx (_Lynx lynx_). We investigated this claim in a closely related species, Canada lynx (_Lynx canadensis_). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted. |
|
 |
PDF files are only accessible to Friends of the Cat Group. Joining Friends of the Cat Group gives you unlimited access and downloads in the Cat SG Library for one year, and allows you to receive our newsletter Cat News (2 regular issues per year plus special issues). More information how to join here |
(c) IUCN/SSC Cat Specialist Group ( IUCN - The World Conservation Union) |